KMID : 1044820230530030218
|
|
Journal of Periodontal & Implant Science 2023 Volume.53 No. 3 p.218 ~ p.232
|
|
Sinus augmentation with poly(¥å) caprolactone-¥â tricalcium phosphate scaffolds, mesenchymal stem cells and platelet rich plasma for one-stage dental implantation in minipigs
|
|
Nam Jeong-Hun
Akram Abdo Almansoori Kwon Oh-Jun Seo Young-Kwon Kim Bong-Ju Kim Young-Kyun Lee Jong-Ho Pang Kang-Mi
|
|
Abstract
|
|
|
Purpose: This study evaluated the efficacy of a tube-shaped poly(¥å) caprolactone - ¥â tricalcium phosphate (PCL-TCP) scaffold with the incorporation of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) and platelet-rich plasma (PRP) for bone regeneration in the procedure of single-stage sinus augmentation and dental implantation in minipigs.
Methods: Implants were placed in the bilateral sides of the maxillary sinuses of 5 minipigs and allocated to a PCL-TCP+hUCMSCs+PRP group (n=5), a PCL-TCP+PRP group (n=5), and a PCL-TCP-only group (n=6). After 12 weeks, bone regeneration was evaluated with soft X-rays, micro-computed tomography, fluorescence microscopy, and histomorphometric analysis.
Results: Four implants failed (2 each in the PCL-TCP+hUCMSCs+PRP and PCLTCP+hUCMSC groups). An analysis of the grayscale levels and bone-implant contact ratio showed significantly higher mean values in the PCL-TCP+hUCMSCs+PRP than in the PCL-TCP group (P=0.045 and P=0.016, respectively). In fluoromicroscopic images, new bone formation around the outer surfaces of the scaffolds was observed in the PCLTCP+hUCMSCs+PRP group, suggesting a tenting effect of the specially designed scaffolds.
Bone regeneration at the scaffold-implant interfaces was observed in all 3 groups.
Conclusions: Using a tube-shaped, honeycombed PCL-TCP scaffold with hUCMSCs and PRP may serve to enhance bone formation and dental implants¡¯ osseointegration in the procedure of simultaneous sinus lifting and dental implantation.
|
|
KEYWORD
|
|
Dental implants, Platelet-rich plasma, Sinus floor augmentation, Stem cells
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|